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Clearance of abnormal IGA1 in IGA1 deposition diseases
Clearance of abnormal IGA1 in IGA1 deposition diseases
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机译:清除IGA1沉积疾病中异常的IGA1
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摘要
The present invention relates to proteins which specifically bind to IgA1 and which have been modified to comprise either O- or N-linked glycans. The invention encompasses methods for decreasing IgA1, preferably abnormally glycosylated IgA1, in an individual by administering to the individual a glycan-modified IgA1 binding protein of the invention. The invention also encompasses a method for the treatment of a disease characterized by IgA1 deposition wherein a glycan-modified IgA1 binding protein is administered to an individual in need thereof.
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