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Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody

机译:抗CD20抗体治疗侵袭性非霍奇金淋巴瘤

摘要

This invention concerns methods for the treatment of intermediate and high-grade non-Hodgkins lymphomas, comprising the administration of anti-CD20 monoclonal antibodies and fragments thereof. Particular embodiments include the administration of chimeric anti-CD20 antibody, either alone or in combination with radiolabeled antibodies or chemotherapy. The invention is particularly useful for lymphomas characterized by a high number of circulating B cells, possibly bone marrow involvement, bulky disease, or the involvement of extralymphatic organs or sites.
机译:本发明涉及治疗中度和高度非霍奇金淋巴瘤的方法,包括给予抗CD20单克隆抗体及其片段。具体的实施方案包括单独或与放射性标记的抗体或化学疗法组合施用嵌合抗CD20抗体。本发明对于以大量循环B细胞为特征的淋巴瘤特别有用,所述B细胞可能是骨髓累及,大块疾病或淋巴外器官或部位的累及。

著录项

  • 公开/公告号US8557244B1

    专利类型

  • 公开/公告日2013-10-15

    原文格式PDF

  • 申请/专利权人 CHRISTINE WHITE;ANTONIO GRILLO-LOPEZ;

    申请/专利号US20000628187

  • 发明设计人 CHRISTINE WHITE;ANTONIO GRILLO-LOPEZ;

    申请日2000-07-28

  • 分类号A61K39/395;A61K31/661;A61K31/664;A61K31/704;A61K31/56;C07K14/705;

  • 国家 US

  • 入库时间 2022-08-21 16:47:44

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