Disclosed are: an oligonucleotide useful for the inhibition of the production of IL-17, the inhibition of the proliferation of a CD4-positive T cell, the amelioration of an inflammation induced by IL-17 or the like; and an NR4A2 gene expression inhibitor, an IL-17 gene expression inhibitor, a CD4-positive T cell proliferation inhibitor or a pharmaceutical composition comprising the oligonucleotide as an active ingredient. Specifically disclosed is siRNA which can inhibit the expression of NR4A2 gene, such as an oligonucleotide having a nucleotide sequence depicted in any one of SEQ ID NOs:1 to 3. The siRNA is useful for the inhibition of the expression of NR4A2 gene, the inhibition of the expression of IL-17 gene, the inhibition of the proliferation of a CD4-positive T cell, the amelioration of an inflammation induced by IL-17 or the like.
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机译：公开了一种寡核苷酸，其可用于抑制IL-17的产生，抑制CD4阳性T细胞的增殖，改善由IL-17诱导的炎症等。 NR4A2基因表达抑制剂，IL-17基因表达抑制剂，CD4阳性T细胞增殖抑制剂或以寡核苷酸为有效成分的药物组合物。具体公开了可抑制NR4A2基因表达的siRNA，例如具有SEQ ID NO：1至3中任一个所示核苷酸序列的寡核苷酸。该siRNA可用于抑制NR4A2基因的表达，即抑制IL-17基因表达的抑制，CD4阳性T细胞增殖的抑制，IL-17诱导的炎症的减轻等。
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