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Pyrrolopyrimidinone carboxamide derivatives, inhibiting CDK or pharmaceutically acceptable salts thereof and pharmaceutical composition for prevention or treatment of the apoptosis in hepatocellular carcinoma cells as an active ingredient
Pyrrolopyrimidinone carboxamide derivatives, inhibiting CDK or pharmaceutically acceptable salts thereof and pharmaceutical composition for prevention or treatment of the apoptosis in hepatocellular carcinoma cells as an active ingredient
PURPOSE: A pharmaceutical composition containing pyrrolopyrimidinone carboxamide derivative is provided to suppress Cdk1 and Cdk2 and to induce apoptosis of cancer cells. CONSTITUTION: A pyrrolopyrimidinone carboxamide derivative is denoted by chemical formula 1. A method for preparing the derivative comprises: a step of BSA to a compound of chemical formula 2 and adding a compound of chemical formula 3 under the presence of TMSOTf to prepare a compound of chemical formula 4; a step of adding ammonium hydroxide solution to the compound of chemical formula 4 to prepare a compound of chemical formula 5; and a step of adding hydrogen peroxide to the compound of chemical formula 5.
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