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NANO COMPLEX FOR RECONSTRUCTION OR REGENERATION OF CHONDROCYTIC TISSUE AND METHOD FOR DIFFERENTIATION TO CHONDROCYTES USING THE SAME
NANO COMPLEX FOR RECONSTRUCTION OR REGENERATION OF CHONDROCYTIC TISSUE AND METHOD FOR DIFFERENTIATION TO CHONDROCYTES USING THE SAME
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机译：用于重建或再生软骨细胞组织的纳米复合物以及使用该纳米复合物分化软骨细胞的方法
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摘要
PURPOSE: A nanocomposite for reconstruction or regeneration of chondrocytes and a method for differentiating stem cells into chondrocytes are provided to effectively deliver hSOX9 gene and siRNA to mesenchymal stem cells. CONSTITUTION: A nanocomposite for reconstruction or regeneration of chondrocytes is prepared by binding hSOX9 gene or nucleotide siRNA containing a base sequence of sequence numbers 1-6 on nanoparticles of biodegradable polymers. The biodegradable polymers are a poly(lactic-co-glycolic acid). The weight ratio of the hSOX9 gene and biodegradable polymers is 1:40-100. A method for differentiating mesenchymal stem cells into chondrocytes comprises a step of culturing the mesenchymal stem cells under the presence of the nanocomosite. A pharmaceutical composition for reconstruction or regeneration of chondrocytes contains the nanocomposite-introduced mesenchymal stem cells and pharmaceutically acceptable carrier.
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