首页> 外国专利> PEPTIDES FOR THE TREATMENT OF CANCER ASSOCIATED WITH THE HUMAN PAPILOMA VIRUS (HPV) AND OTHER EPITELIAL TUMORS.

PEPTIDES FOR THE TREATMENT OF CANCER ASSOCIATED WITH THE HUMAN PAPILOMA VIRUS (HPV) AND OTHER EPITELIAL TUMORS.

机译：用于治疗与人乳头瘤病毒（HPV）和其他上皮性肿瘤相关的肽。

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摘要

Peptides useful for the treatment of tumors of epithelial origin and especially those associated with oncogenic types of Papillomavirus (HPV). Identification of peptides whose structure allows the blocking of the phosphorylation domain by Casein Kinase II (CKII) by direct interaction with said site. In the present invention, eleven peptides of different cyclic structure and amino acid sequence are shown, which inhibit the phosphorylation site by CKII in vitro, produce cytotoxicity in human cervical carcinoma cells transformed by HPV-16 (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of Interferon (IFN). The invention also relates to the use of these peptides conjugated or fused to other peptides and chemical compounds of intracellular penetration as well as to the use of mimetic molecules of both peptide and chemical origin.

机译：肽可用于治疗上皮来源的肿瘤，尤其是与致癌类型的乳头瘤病毒（HPV）相关的肽。鉴定其结构允许酪蛋白激酶II（CKII）通过与所述位点直接相互作用来阻断其磷酸化结构域的肽。在本发明中，显示了十一种具有不同环状结构和氨基酸序列的肽，其在体外抑制CKII的磷酸化位点，在由HPV-16（CaSki）转化的人宫颈癌细胞中产生细胞毒性，并且还增加了它们的敏感性。细胞对干扰素（IFN）的抑制细胞作用。本发明还涉及与其他肽缀合或融合的这些肽和细胞内渗透的化学化合物的用途，以及涉及肽和化学来源的模拟分子的用途。

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公开/公告号ES2371239T3

专利类型
公开/公告日2011-12-28

原文格式PDF
申请/专利权人 CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIGB);
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申请/专利号ES20020796490T
发明设计人 PEREA RODRIGUEZ SILVIO ERNESTO;REYES ACOSTA OSVALDO;SANTIAGO VISPO NELSON FRANCISCO;PUCHADES IZAGUIRRE YAQUELIN;SILVA RODRIGUEZ RICARDO;MORO SORIA ALEJANDRO;SANTOS SAVIO ALICIA;GONZALEZ LOPEZ LUIS JAVIER;GONZALEZ BARRIOS BELKIS;
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申请日2002-12-04
分类号C07K7/64;C12N15/09;A61K38;A61K38/08;A61K38/12;A61K38/19;A61K38/21;A61K38/55;A61P35;A61P43;C07K7/06;C07K14/025;C12N15/63;
国家 ES
入库时间 2022-08-21 17:21:16

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