首页> 外国专利> RNA Interference Mediated Inhibition of the High Affinity 1 gE Receptor Alpha Chain (FC Epsilon R1 Alpha) Gene Expression Using Short Interfering Nucleic Acid (siNA)

RNA Interference Mediated Inhibition of the High Affinity 1 gE Receptor Alpha Chain (FC Epsilon R1 Alpha) Gene Expression Using Short Interfering Nucleic Acid (siNA)

机译:RNA干扰介导的高亲和力1 gE受体α链(FC Epsilon R1 Alpha)基因表达的抑制,使用短干扰核酸(siNA)

摘要

The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of FCεR1α gene expression and/or or activity, and/or modulate a FCεR1α gene expression pathway. Specifically, the invention relates to doublestranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against FCεR1α gene expression.
机译:本发明涉及用于研究,诊断和治疗对FCεR1α基因表达和/或活性的调节有反应和/或调节FCεR1α基因表达途径的性状,疾病和病状的化合物,组合物和方法。具体地,本发明涉及包括小核酸分子的双链核酸分子,例如短干扰核酸(siNA),短干扰RNA(siRNA),双链RNA(dsRNA),微小RNA(miRNA)和短核酸。能够介导或介导针对FCεR1α基因表达的RNA干扰(RNAi)的发夹RNA(shRNA)分子。

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