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Attenuated live triple G protein recombinant rabies virus vaccine for pre- and post-exposure prophylaxis of rabies
Attenuated live triple G protein recombinant rabies virus vaccine for pre- and post-exposure prophylaxis of rabies
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机译:减毒活三联G蛋白重组狂犬病毒疫苗,用于狂犬病暴露前和暴露后的预防
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摘要
The invention provides a recombinant rabies viruses comprising three copies of a mutated G gene wherein each G gene encodes a rabies virus glycoprotein having the amino acid 194 mutated to a serine and the amino acid 333 is mutated to a glutamic acid. The recombinant rabies virus is nonpathogenic in immunodeficient mammals and can be used in a vaccine to induce an immune response protect mammals from infection by rabies virus as well as clear a pre-existing rabies virus infection from neural tissues.
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