首页> 外国专利> Attenuated Live Triple G Protein Recombinant Rabies Virus Vaccine for Pre- and Post-Exposure Prophylaxis of Rabies

Attenuated Live Triple G Protein Recombinant Rabies Virus Vaccine for Pre- and Post-Exposure Prophylaxis of Rabies

机译:减毒的活三G蛋白重组狂犬病病毒疫苗,用于狂犬病的暴露前和暴露后预防

摘要

The invention provides a recombinant rabies viruses comprising three copies of a mutated G gene wherein each G gene encodes a rabies virus glycoprotein having the amino acid 194 mutated to a serine and the amino acid 333 is mutated to a glutamic acid. The recombinant rabies virus is nonpathogenic in immunodeficient mammals and can be used in a vaccine to induce an immune response protect mammals from infection by rabies virus as well as clear a pre-existing rabies virus infection from neural tissues.
机译:本发明提供了包含三个拷贝的突变的G基因的重组狂犬病毒,其中每个G基因编码狂犬病毒糖蛋白,所述狂犬病毒糖蛋白的氨基酸194突变为丝氨酸,而氨基酸333突变为谷氨酸。重组的狂犬病病毒在免疫缺陷的哺乳动物中是非致病性的,可用于疫苗中以诱导免疫反应,从而保护哺乳动物免受狂犬病病毒的感染,并从神经组织清除先前存在的狂犬病病毒感染。

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