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EXPRESSION SYSTEM USING MAMMALIAN -ACTIN PROMOTER
EXPRESSION SYSTEM USING MAMMALIAN -ACTIN PROMOTER
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机译:哺乳动物肌动蛋白启动子的表达系统
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摘要
PROBLEM TO BE SOLVED: To provide promoters stronger than animal cell expression promoters, and vectors using the same, in technologies making animal cells efficiently produce recombinant proteins.SOLUTION: There is provided a hybrid promoter comprising a combination of a CMV (cytomegalovirus) enhancer and a mammalian -actin promoter, or the post-transcriptional regulatory region of the genomic sequence of Woodchuck Hepatitis Virus (WPRE) and the mammalian -actin promoter. Further, the -actin promoter is enhanced in activity by the simultaneous expression of an oncogene product Ras which is a transactivator.
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