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SEQUENCES, ANTIBODIES, METHODS AND NECESSARY FOR DETECTION AND IN VITRO ASSAYING OF PERIOSTIN FOR THE DIAGNOSIS OF MONITORING OR PROGNOSIS OF PATHOLOGIES OR BIOLOGICAL PHENOMENA INVOLVING PERIOSTIN
SEQUENCES, ANTIBODIES, METHODS AND NECESSARY FOR DETECTION AND IN VITRO ASSAYING OF PERIOSTIN FOR THE DIAGNOSIS OF MONITORING OR PROGNOSIS OF PATHOLOGIES OR BIOLOGICAL PHENOMENA INVOLVING PERIOSTIN
The invention relates to novel SP detection sequences of periostin. These sequences have from 6 to 30 amino acids and include all or part of the peptide sequence SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3 or a peptide sequence homologous thereto. The invention also relates to antibodies capable of specifically recognizing at least one of these detection sequences, preferably an anti-periostin antibody. The invention also relates to methods and kits for detecting and assaying periostin using these antibodies. In doing so, the invention provides a periostin marker for early diagnosis, monitoring and prognosis of pathologies that involve periostin, as they are accompanied by benign osteolysis (inflammatory diseases: osteoarticular diseases) or malignant (cancers with metastases bone).
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机译：本发明涉及骨膜蛋白的新型SP检测序列。这些序列具有6至30个氨基酸，并且包括全部或部分肽序列SEQ ID No.1，SEQ ID No.2或SEQ ID No.3或与其同源的肽序列。本发明还涉及能够特异性识别这些检测序列中的至少一个的抗体，优选抗骨膜素抗体。本发明还涉及使用这些抗体检测和测定骨膜蛋白的方法和试剂盒。这样做，本发明提供了一种骨膜素标记物，用于与骨膜素有关的病理的早期诊断，监测和预后，因为它们伴有良性骨溶解（炎性疾病：骨关节疾病）或恶性（伴有骨转移癌）。
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