首页> 外国专利> METHOD OF INTRAOPERATIVE INTRACAVITY HYPERTHERMIC CHEMOTHERAPY IN DISSEMINATED ABDOMINAL AND PELVIC CANCER IN HUMAN

METHOD OF INTRAOPERATIVE INTRACAVITY HYPERTHERMIC CHEMOTHERAPY IN DISSEMINATED ABDOMINAL AND PELVIC CANCER IN HUMAN

机译：腹腔镜和人宫颈癌术中术中难治性高热化疗的方法

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摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to oncology, and can be used in therapy of disseminated abdominal and pelvic cancer. The method involves the preoperative patient positioning on a mattress heated to temperature 37-39°C, the removal of primary and secondary cancer foci, the installation of drainage tubes in the abdominal and pelvic cavities. Thereafter, a reservoir is created to be filled with a perfusion solution specified from dialysis solution, Ringer's solution or 5% glucose and containing Oxaliplatin in dosage 50-130 mg/m² or Mitomycin C in dosage 20 mg/m² and 5-fluorouracil in dosage 1 g/m². The stage of the initiation and during hyperthermic chemotherapy involves the forced cooling of the patient's occiput and cervical great vessels. For the hyperthermic chemotherapy, the perfusion solution of temperature 43-48°C is used, and for the postoperative chemotherapy, the chemotherapeutic solution of temperature 37-38°C is introduced through the kept drainages.;EFFECT: method allows to prevent tumour cell penetration into the vascular and lymphatic bed due to combined high-temperature, sensitising and cytotoxic action of the high concentrated chemopreparations in tumour tissue.;31 cl, 11 ex

机译：领域：药物;发明：本发明是指药物，即肿瘤学，并且可用于治疗弥漫性腹部和骨盆癌。该方法包括将术前患者放在加热到37-39°C的床垫上，去除原发和继发癌灶，在腹腔和骨盆腔中安装引流管。此后，创建一个容器，以填充透析液，林格氏液或5％葡萄糖中指定的灌注溶液，其中含有50-130 mg / m ^{2 的奥沙利铂或20 mg的丝裂霉素/ m ^{2 和5-氟尿嘧啶，剂量为1 g / m ^{2 。初始阶段以及在高温化学疗法过程中，都需要强制冷却患者的枕骨和颈大血管。对于高温化学疗法，使用温度为43-48°C的灌注溶液，对于术后化学疗法，通过保持的引流管引入温度为37-38°C的化学疗法溶液;效果：该方法可防止肿瘤细胞高浓度化学制剂在肿瘤组织中的高温，敏化作用和细胞毒性作用共同渗透到血管和淋巴床中; 31 cl，11 ex}}}

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公开/公告号RU2406451C2

专利类型
公开/公告日2010-12-20

原文格式PDF
申请/专利权人 KITAEV ALEKSANDR VASILEVICH;
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申请/专利号RU20080148246
发明设计人 ROMANOVSKAJA SVETLANA VIKTOROVNA;PAVLOV ARTEM VIKTOROVICH;PETROV VALENTIN PAVLOVICH;ABDULAEV KHALIL RASHIDOVICH;LJUTSKIJ VLADIMIR IGOREVICH;KITAEV ALEKSANDR VASILEVICH;AZBAROV ANATOLIJ AKIMOVICH;MUSLIMOV MUSLIM ILDRYM OGLY;BYKHOVETS IGOR VASILEVICH;
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申请日2008-12-09
分类号A61B17/00;A61K31/282;A61K31/513;A61K31/7036;A61P35/00;
国家 RU
入库时间 2022-08-21 17:48:36

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