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APPLICATION OF A GEL FROM NATURAL POLYSACCHARIDE (NATURAL POLYSACCHARIDES) FOR PREPARING AN APPLICABLE FOR INJECTION COMPOSITION IN TREATMENT OF JOINT DENEGENIA
APPLICATION OF A GEL FROM NATURAL POLYSACCHARIDE (NATURAL POLYSACCHARIDES) FOR PREPARING AN APPLICABLE FOR INJECTION COMPOSITION IN TREATMENT OF JOINT DENEGENIA
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机译：天然多糖凝胶（天然多糖）在制备治疗关节异位症的注射组合物中的应用
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摘要
1. A sterile aqueous, injectable composition for use in the joints in the form of a gel containing hyaluronic acid in an amount of 1-100 mg / ml or one of its salts and, if necessary, one or more other polysaccharides of natural origin, as well as one or several polyhydric alcohols in an amount of 0.0001-100 mg / ml, obtained by preparing an aqueous composition containing hyaluronic acid or one of its salts, if necessary, one or more other polysaccharides of natural origin, as well as one or several Olka polyols and sterilizing said composition! the gel obtained has a frequency of coincidence of the elastic modulus G 'and the viscosity modulus G "from 0 to 10 Hz, preferably 0.41 Hz ± 0.41 Hz, while G" exceeds G' at a high coincidence frequency of the modules. ! 2. The composition according to claim 1, in which hyaluronic acid does not contain or practically does not contain cross-links. ! 3. The composition according to claim 1, in which hyaluronic acid contains cross-links. ! 4. The composition according to claim 2, in which the concentration of hyaluronic acid or one of its salts is 10-25 mg / ml, and the concentration of polyhydric alcohol (polyhydric alcohols) is 15-45 mg / ml. ! 5. The composition according to claim 1, in which hyaluronic acid (or one of its salts), separately or in a mixture, has a molecular weight of from 0.1 to 10 · 106 Yes, and the polyhydric alcohol, separately or in a mixture, is glycerin , propylene glycol, sorbitol, mannitol or glucose. ! 6. The composition according to claim 1, in which hyaluronic acid has a molecular weight of from 2 to 3 · 106 Da. ! 7. The composition according to claim 1, in which the concentration of hyaluronic acid is 20 mg / ml, the concentration of glycerol is
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