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Recombinant Gram-negative Bacteria Producing Outer Membrane Vesicles and Method for Preparing Outer Membrane Vesicles Tagged with Foreign Epitopes Using the Same
Recombinant Gram-negative Bacteria Producing Outer Membrane Vesicles and Method for Preparing Outer Membrane Vesicles Tagged with Foreign Epitopes Using the Same
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机译:重组革兰氏阴性菌生产外膜囊泡和使用外来抗原表位标记的外膜囊泡的制备方法
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摘要
The present invention relates to recombinant gram-negative (G(-)) bacteria producing outer membrane vesicles and a method for preparing outer membrane vesicles tagged with multivalent epitopes using the recombinant bacteria. Outer membrane vesicles (OVMs) produced from the inventive recombinant G(-) bacteria are safer than outer membrane vesicles produced from wild-type bacteria and, at the same time, have the ability to deliver multivalent epitopes, and self- adjuvanticity. Thus, the inventive outer membrane vesicles produced from the recombinant G(-) bacteria are useful as noble bio-nano particulate vaccines.
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