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FORMULATION AND METHOD FOR RAPID PREPARATION OF ISOTONIC AND CYTOCOMPATIBLE CHITOSAN SOLUTIONS WITHOUT INDUCING CHITOSAN PRECIPITATION
FORMULATION AND METHOD FOR RAPID PREPARATION OF ISOTONIC AND CYTOCOMPATIBLE CHITOSAN SOLUTIONS WITHOUT INDUCING CHITOSAN PRECIPITATION
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机译：在不引起壳聚糖沉淀的情况下快速制备等渗和细胞相容性壳聚糖溶液的配方和方法
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摘要
The present disclosure is directed to a two-part cytocompatible system for preparing a cytocompatible composition for use in repairing tissue of a subject. The system comprises an admixture of a first-part liquid solution of a polysaccharide, such as chitosan and a second-part liquid solution of a salt, such as glycerol phosphate. When the chitosan and glycerol phosphate solutions are combined, a cytocompatible composition is produced which is free of polymer precipitation at room temperature. The composition also promotes non-covalent complex formation between chitosan and therapeutic anionic proteins with a pl 6 78.
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