首页> 外国专利> USE OF TAT OF HIV-1 BIOLOGICALLY ACTIVE, FRAGMENTS OR DERIVATIVES OF THE SAME, TO ADDRESS AND / OR ACTIVATE ANTIGEN PRESENTATION CELLS, AND / OR TO SUPPLY MOLECULES CHARGE FOR PREVENTIVE OR THERAPEUTIC OR THERAPEUTIC OR VACCINE AND /.

USE OF TAT OF HIV-1 BIOLOGICALLY ACTIVE, FRAGMENTS OR DERIVATIVES OF THE SAME, TO ADDRESS AND / OR ACTIVATE ANTIGEN PRESENTATION CELLS, AND / OR TO SUPPLY MOLECULES CHARGE FOR PREVENTIVE OR THERAPEUTIC OR THERAPEUTIC OR VACCINE AND /.

机译：使用HIV-1生物活性，其片段或衍生物的TAT来寻址和/或激活抗原表达细胞，和/或供应分子电荷以进行预防或治疗或治疗或疫苗和/。

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摘要

A pharmaceutical composition comprising an isolated, native, substantially monomeric biologically active HIV Tat, or an isolated fragment or an isolated derivative thereof, wherein the HIV Tat, fragment, or derivative: (i) contains the RGD domain of an Tat of HIV-1; (ii) it has adjuvant activity; and (iii) is mixed with an antigenic molecule chosen from the group consisting of: (a) an antigen of a tumor cell; and (b) an antigen of a pathogen, wherein said pathogen is herpes virus, hepatitis virus, influenza virus, chickenpox virus, Epstein-Barr virus, human herpes 8 virus, cytomegalovirus, virus of papilloma, Mycobacterium tuberculosis, Listeria, Streptococcus, Staphylococcus, Pneumococcus, Clostridium tetani, Mycobacterium, Meningococcus, Helicobacter, Salmonella, Vibrio cholerae, Candida, or Plasmodium.

机译：药物组合物，其包含分离的，天然的，基本上单体的具有生物活性的HIV Tat或其分离的片段或分离的衍生物，其中所述HIV Tat，片段或衍生物：（i）包含HIV-1的Tat的RGD结构域。 ; （ii）具有佐剂活性; （iii）与选自以下的抗原性分子混合：（a）肿瘤细胞的抗原; （b）病原体的抗原，其中所述病原体是疱疹病毒，肝炎病毒，流感病毒，水痘病毒，爱泼斯坦-巴尔病毒，人疱疹8病毒，巨细胞病毒，乳头瘤病毒，结核分枝杆菌，李斯特菌，链球菌，葡萄球菌，肺炎球菌，破伤风梭菌，分枝杆菌，脑膜炎球菌，幽门螺杆菌，沙门氏菌，霍乱弧菌，念珠菌或疟原虫。

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公开/公告号ES2367255T3

专利类型
公开/公告日2011-10-31

原文格式PDF
申请/专利权人 ISTITUTO SUPERIORE DI SANITA;
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申请/专利号ES20020767265T
发明设计人 ENSOLI BARBARA;
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申请日2002-07-26
分类号A61K39;C12N15/09;A61K31/711;A61K35/74;A61K35/76;A61K38;A61K39/02;A61K39/04;A61K39/12;A61K39/39;A61K39/395;A61K45;A61K48;A61P1;A61P1/04;A61P3/10;A61P5/14;A61P9;A61P9/10;A61P11;A61P13/02;A61P15;A61P17;A61P17/06;A61P19;A61P19/02;A61P25;A61P27/02;A61P27/06;A61P29;A61P31;A61P31/04;A61P31/06;A61P31/12;A61P31/16;A61P31/22;A61P33;A61P35;A61P37/02;A61P37/08;C07K14/16;
国家 ES
入库时间 2022-08-21 18:02:30

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