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ANTHRANILIC ACID AMID DERIVATIVES AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS

机译：邻氨基苯甲酸衍生物及其作为VEGF受体酪氨酸激酶抑制剂的用途

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摘要

The invention relates to anthranilic acid amide derivatives of formula I, wherein R1 represents H or lower alkyl, R2 represents H or lower alkyl, R3 represents perfluoro lower alkyl, and X is O or S, or an N-oxide or a tautomer thereof, to salts of such anthranilic acid amides, their N-oxides and their tautomers; processes for the preparation thereof, the application thereof for the treatment of the human or animal body, the use thereof-alone or in combination with one or more other pharmaceutically active compounds-for the treatment especially of a neoplastic disease, such as a tumor disease, of retinopathy or age-related macular degeneration; a method for the treatment of such a disease in animals, especially in humans, and the use of such a compound-alone or in combination with one or more other pharmaceutically active compounds-for the manufacture of a pharmaceutical preparation for the treatment of a neoplastic disease, of retinopathy or age-related macular degeneration.

机译：本发明涉及式I的邻氨基苯甲酸酰胺衍生物，其中R 1代表H或低级烷基，R 2代表H或低级烷基，R 3代表全氟低级烷基，X为O或S，或N-氧化物或其互变异构体，此类邻氨基苯甲酰胺的盐，其N-氧化物和互变异构体;的制备方法，其在人体或动物体内的治疗应用，其单独使用或与一种或多种其他药物活性化合物结合使用的方法，尤其是用于治疗肿瘤疾病，例如肿瘤疾病的用途视网膜病变或与年龄相关的黄斑变性;一种在动物，特别是人类中治疗这种疾病的方法，以及这种化合物单独使用或与一种或多种其他药物活性化合物组合用于制备治疗肿瘤的药物的用途视网膜病变或与年龄相关的黄斑变性的疾病。

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公开/公告号AT496889T

专利类型
公开/公告日2011-02-15

原文格式PDF
申请/专利权人 NOVARTIS AG;
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申请/专利号AT20020787595T
发明设计人 BOLD GUIDO;FURET PASCAL;MANLEY PAUL;
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申请日2002-11-07
分类号C07D213/64;A61K31/44;A61K31/4412;A61P9/10;A61P9/14;A61P11/06;A61P15;A61P17/06;A61P19/02;A61P27/02;A61P29;A61P35;A61P35/02;A61P43;C07D213/70;
国家 AT
入库时间 2022-08-21 18:03:33

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