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Use of low-dose erythropoietin for the treatment of acute or chronic kidney failure and for the treatment of wounds

机译:低剂量促红细胞生成素在治疗急性或慢性肾衰竭和伤口治疗中的用途

摘要

Disclosed is the use of erythropoietin and/or a derivate thereof in the preparation of a pharmaceutical composition for administration of a subpolycythemic dosage of from 1 to 90 IU/kg of body weight per week of the erythropoiten and/or derivative thereof for the treatment of acute or chronic renal failure in a human or animal patient exhibiting: a) at least one dysfunction of endothelial progenitor cells, and b) at least one cardiovascular risk factor, wherein the at least one cardiovascular risk factor is selected from the group consisting of hypertension, hypercholesterolemia, elevated asymmetric dimethylarginine (ADMA) levels, increased insulin resistance and hyperhomocysteinemia, and c) at least one end-organ damage, wherein the at least one end-organ damage is selected from the group consisting of left ventricular hypertrophy, microalbuminuria, cognitive dysfunction, increased thickness of the intima media in the carotid artery, proteinuria and a glomerular filtration rate of 30 to 80 ml/min, and wherein the pharmaceutical composition is for the treatment of beginning kidney tissue and/or function damage to provide diminution of the progression or regeneration of the beginning tissue and/or function damage.
机译:公开了促红细胞生成素和/或其衍生物在制备药物组合物中的用途,所述药物组合物用于以每周1至90IU / kg体重的剂量给予多囊性红细胞生成素和/或其衍生物,用于治疗人类或动物患者的急性或慢性肾衰竭,表现为:a)至少一种内皮祖细胞功能障碍,和b)至少一种心血管危险因素,其中至少一种心血管危险因素选自高血压,高胆固醇血症,不对称二甲基精氨酸(ADMA)水平升高,胰​​岛素抵抗和高同型半胱氨酸血症增加,以及c)至少一种终末器官损害,其中至少一种终末器官损害选自左心室肥大,微量白蛋白尿,认知功能障碍,颈动脉内膜中层厚度增加,蛋白尿和肾小球滤过率30剂至80ml / min,并且其中药物组合物用于治疗开始的肾组织和/或功能损伤以减少开始的组织和/或功能损伤的进展或再生。

著录项

  • 公开/公告号NZ548697A

    专利类型

  • 公开/公告日2011-01-28

    原文格式PDF

  • 申请/专利权人 EPOPLUS GMBH & CO. KG;

    申请/专利号NZ20050548697

  • 发明设计人 BAHLMANN FERDINAND HERMANN;HALLER HERMANN;

    申请日2005-01-22

  • 分类号A61K38/18;A61K8/64;A61Q1;A61Q7;A61Q17;A61Q19;A61Q19/08;

  • 国家 NZ

  • 入库时间 2022-08-21 18:05:10

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