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Use of low-dose erythropoietin for the treatment of acute or chronic kidney failure and for the treatment of wounds
Use of low-dose erythropoietin for the treatment of acute or chronic kidney failure and for the treatment of wounds
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机译:低剂量促红细胞生成素在治疗急性或慢性肾衰竭和伤口治疗中的用途
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摘要
Disclosed is the use of erythropoietin and/or a derivate thereof in the preparation of a pharmaceutical composition for administration of a subpolycythemic dosage of from 1 to 90 IU/kg of body weight per week of the erythropoiten and/or derivative thereof for the treatment of acute or chronic renal failure in a human or animal patient exhibiting: a) at least one dysfunction of endothelial progenitor cells, and b) at least one cardiovascular risk factor, wherein the at least one cardiovascular risk factor is selected from the group consisting of hypertension, hypercholesterolemia, elevated asymmetric dimethylarginine (ADMA) levels, increased insulin resistance and hyperhomocysteinemia, and c) at least one end-organ damage, wherein the at least one end-organ damage is selected from the group consisting of left ventricular hypertrophy, microalbuminuria, cognitive dysfunction, increased thickness of the intima media in the carotid artery, proteinuria and a glomerular filtration rate of 30 to 80 ml/min, and wherein the pharmaceutical composition is for the treatment of beginning kidney tissue and/or function damage to provide diminution of the progression or regeneration of the beginning tissue and/or function damage.
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