首页> 外国专利> PROTEINS COMPRISING CONSERVED REGIONS OF NEISSERIA MENINGITIDIS SURFACE ANTIGEN NhhA FOR USE AS A VACCINE AGAINST MULTIPLE STRAINS OF NEISSERIA MENINGITIDIS

PROTEINS COMPRISING CONSERVED REGIONS OF NEISSERIA MENINGITIDIS SURFACE ANTIGEN NhhA FOR USE AS A VACCINE AGAINST MULTIPLE STRAINS OF NEISSERIA MENINGITIDIS

机译：包含猪奈瑟氏球菌表面抗原NhhA保守区的蛋白，可用于疫苗抵抗多株奈瑟氏球菌

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摘要

Novel proteins that constitute modified forms of a Neisseria meningitidis surface antigen and encoding nucleic acids are provided. The modified surface proteins are characterized by having deletions of non-conserved amino acids, and thereby being capable of eliciting cross-protective immune responses against Neisseria meningitidis. The invention extends to the use of the modified surface antigens in diagnostics, in therapeutic and prophylactic vaccines and in the design and/or screening of medicaments. The modified surface antigens are particularly usefulin vaccines which effectively immunize against a broader spectrum of N. meningitidis strains than would be expected from a corresponding wild-type surface antigen.

机译：提供了构成脑膜炎奈瑟氏球菌表面抗原的修饰形式并编码核酸的新型蛋白质。修饰的表面蛋白的特征在于具有非保守氨基酸的缺失，从而能够引起针对脑膜炎奈瑟氏球菌的交叉保护性免疫应答。本发明扩展到修饰的表面抗原在诊断，治疗和预防性疫苗以及药物的设计和/或筛选中的用途。修饰的表面抗原在疫苗中特别有用，该疫苗能有效地抵抗比相应的野生型表面抗原所预期的更广谱的脑膜炎奈瑟氏球菌菌株。

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公开/公告号IL150822A

专利类型
公开/公告日2011-06-30

原文格式PDF
申请/专利权人 THE UNIVERSITY OF QUEENSLAND;
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申请/专利号IL20020150822
发明设计人
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申请日2002-07-18
分类号C12N15/09;A61K31/7088;A61K35/76;A61K38;A61K39;A61K39/095;A61K48;A61P31/04;C07K14/22;C12N1/21;C12N15/31;C12R1/36;
国家 IL
入库时间 2022-08-21 18:06:25

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