首页> 外国专利> methods for detecting non-viable neoplastic cells in an individual, for evaluating and / or monitoring a neoplastic condition and the effectiveness of a neoplasm therapeutic treatment regimen in an individual, and for treating a neoplastic condition and metastatic cancer in an individual, diagnostic kit for a biological sample, use of an interactive molecule, pharmaceutical composition, and agent

methods for detecting non-viable neoplastic cells in an individual, for evaluating and / or monitoring a neoplastic condition and the effectiveness of a neoplasm therapeutic treatment regimen in an individual, and for treating a neoplastic condition and metastatic cancer in an individual, diagnostic kit for a biological sample, use of an interactive molecule, pharmaceutical composition, and agent

机译：用于检测个体中无活力的赘生性细胞，评估和/或监测个体中的赘生性疾病和肿瘤治疗方案的有效性以及在个体中用于治疗赘生性疾病和转移性癌症的方法生物样品，相互作用分子的用途，药物组合物和试剂

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摘要

METHODS FOR DETECTING NEOPLASTIC CELLS NOT AVAILABLE IN AN INDIVIDUAL TO EVALUATE AND / OR MONITOR A NEOPLASTIC CONDITION AND THE EFFECTIVENESS OF A NEUTRAL THERAPEUTIC TREATMENT SCHEME IN AN INDIVIDUAL CONDUCT AND A METHOD FOR A BIOLOGICAL SAMPLE, USE OF AN INTERACTIVE MOLECULE, PHARMACEUTICAL COMPOSITION, AND, AGENT. The present invention generally relates to a method of screening for neoplastic cell death level in an individual. More particularly, the present invention provides a method of screening for neoplastic cell death level by detecting the level of telomerase gene and / or protein expression by cells killed in said individual or in a biological sample derived from said individual. The method of the present invention is useful within a variety of applications including, but not limited to, assessing a neoplastic condition, monitoring the progress of such a condition, assessing the effectiveness of a therapeutic agent or therapeutic regimen, and predicting the possibility that an individual either progresses to a more advanced disease state or enters a remissive state. The present invention also provides diagnostic agents useful for detecting nucleic acid and / or protein telomerase molecules.

机译：用于评估和/或监测肿瘤状态的单个细胞的方法以及在个体行为中中性治疗方案的有效性以及生物学样品，药物，药物，药物，药物，药物和药物的方法，代理商。本发明一般涉及筛选个体中肿瘤细胞死亡水平的方法。更具体地，本发明提供了通过检测在所述个体或源自所述个体的生物学样品中被杀死的细胞的端粒酶基因和/或蛋白质表达的水平来筛选赘生性细胞死亡水平的方法。本发明的方法可用于多种应用中，包括但不限于评估肿瘤性疾病，监测此类疾病的进展，评估治疗剂或治疗方案的有效性以及预测可能的疾病。个体要么进入疾病晚期，要么进入缓解状态。本发明还提供了用于检测核酸和/或蛋白质端粒酶分子的诊断剂。

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公开/公告号BRPI0608679A2

专利类型
公开/公告日2010-12-07

原文格式PDF
申请/专利权人 MEDVET SCIENCE PTY. LTD.;
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申请/专利号BR2006PI08679
发明设计人 MICHALE PAUL BROWN;
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申请日2006-03-31
分类号G01N33/574;A61K39/395;A61K51/10;A61P35;C12Q1/68;G01N33/53;G01N33/577;
国家 BR
入库时间 2022-08-21 18:07:16

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