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1-amido-4-phenyl-4-benzyloxymethyl-piperidine derivatives and related compounds as neurokinin-1 (NK-1) antagonists for the treatment of vomiting, depression, anxiety and cough

机译：1-酰胺基-4-苯基-4-苄氧基甲基-哌啶衍生物和相关化合物作为神经激肽-1（NK-1）拮抗剂，用于治疗呕吐，抑郁，焦虑和咳嗽

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摘要

Disclosed are NKSUB1 /SUBantagonists having the formula: Also disclosed are methods for treating a number of physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough, using the compounds of formula (I).

机译：公开了具有下式的NK _{1 拮抗剂：还公开了使用式（I）化合物治疗多种生理疾病，症状或疾病的方法，包括呕吐，抑郁，焦虑和咳嗽。}

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公开/公告号JP4592077B2

专利类型
公开/公告日2010-12-01

原文格式PDF
申请/专利权人シェーリングコーポレイション;
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申请/专利号JP20040519752
发明设计人シー;ネン－ヤン;ワン;スティーブン;リチャード;グレゴリーエー．;シャオ;ドン;ワン;チェン;
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申请日2003-07-02
分类号C07D211/98;A61K31/451;A61K31/4525;A61K31/4535;A61K31/454;A61K31/496;A61K31/5377;A61K31/573;A61K45;A61P1/04;A61P1/08;A61P1/14;A61P3/04;A61P3/10;A61P9/10;A61P11;A61P13/02;A61P13/10;A61P15;A61P17;A61P19/04;A61P25;A61P25/04;A61P25/06;A61P25/08;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P25/36;A61P27/02;A61P29;A61P29/02;C07D401/04;C07D401/12;C07D405/12;C07D409/12;C07D413/04;C07D413/12;C07D417/12;C07D417/14;
国家 JP
入库时间 2022-08-21 18:17:06

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