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Artificially synthesized CpG single-chain deoxyoligonucleotide and its antiviral activity

机译:人工合成的CpG单链脱氧寡核苷酸及其抗病毒活性

摘要

The present invention provides a series of artificial CpG-containing single-stranded oligodeoxynucleotides (ODNs), each of which is consisted of single-stranded oligodeoxynucleotide DNA molecule containing one or more CpG(s), wherein said ODNs can stimulate human peripheral blood mononuclear cell (PBMC) to produce antiviral substances. These ODNs can protect the cells against the attack from virus, wherein said virus is preferably selected from the group consisted of influenza virus and single-stranded positive strand RNA virus such as SARS virus, hepatitis C virus, dengue virus and Japanese encephalitis virus. Moreover, the antiviral use of artificial CpG ODNs and its use for treating and preventing viral infection are also provided.
机译:本发明提供了一系列的含有人工CpG的单链寡脱氧核苷酸(ODN),每个由含有一个或多个CpG的单链寡脱氧核苷酸DNA分子组成,其中所述ODN可以刺激人外周血单核细胞(PBMC)产生抗病毒物质。这些ODN可以保护细胞免受病毒的攻击,其中所述病毒优选选自流感病毒和单链正链RNA病毒,例如SARS病毒,丙型肝炎病毒,登革热病毒和日本脑炎病毒。此外,还提供了人工CpG ODN的抗病毒用途及其在治疗和预防病毒感染中的用途。

著录项

  • 公开/公告号JP4809220B2

    专利类型

  • 公开/公告日2011-11-09

    原文格式PDF

  • 申请/专利权人 長春華普生物技術有限公司;

    申请/专利号JP20060521375

  • 发明设计人 于永利;王麗穎;

    申请日2004-07-26

  • 分类号C12N15/117;A61K31/711;A61K39/12;A61P31/14;

  • 国家 JP

  • 入库时间 2022-08-21 18:19:59

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