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首页> 外国专利> METHOD TO USE FIBROBLAST OR SUPERNATANT FROM FIBROBLAST FOR IMMUNE RESPONSE INHIBITION IN TRANSPLANTATION, AND COMPOSITION OF THE SAME

METHOD TO USE FIBROBLAST OR SUPERNATANT FROM FIBROBLAST FOR IMMUNE RESPONSE INHIBITION IN TRANSPLANTATION, AND COMPOSITION OF THE SAME

机译：用成纤维细胞或成纤维细胞上清液用于移植中免疫反应抑制的方法及其组成

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PPROBLEM TO BE SOLVED: To provide a method and a composition for immune response inhibition in transplantation. PSOLUTION: The method is one method to induce so as to reduce an immune response in a recipient by treating the recipient with a quantity of a fibroblast or a supernatant from a fibroblast culture substance effective to reduce or inhibit host rejection of a transplant. The fibroblast or the supernatant from the fibroblast culture substance is administered before, at the same time as, or after the transplantation. The method is effective in reducing the immune response to the transplant without compromising the immune response to other external antigen. Furthermore, a method to induce reducing the immune response against a host by external tissue, that is, graft versus host disease is disclosed. PCOPYRIGHT: (C)2011,JPO&INPIT
机译：

要解决的问题：提供一种用于移植中免疫应答抑制的方法和组合物。

解决方案：该方法是一种诱导方法，可通过用一定量的成纤维细胞或成纤维细胞培养物中的上清液处理受体来降低受体的免疫反应，所述成纤维细胞或上皮细胞培养物的上清液可有效减少或抑制宿主的排斥反应。在移植之前，同时或之后施用成纤维细胞或来自成纤维细胞培养物的上清液。该方法有效地减少了对移植物的免疫反应，而不损害对其他外部抗原的免疫反应。此外，公开了一种诱导减少外部组织对宿主的免疫应答的方法，即移植物抗宿主疾病。

版权：（C）2011，日本特许厅＆INPIT

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