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METHOD OF TREATING CONGENITAL STRUCTURAL MYOPATHIES AND CONGENITAL MUSCULAR DYSTROPHIES BY CORRECTION OF SECONDARY MITOCHONDRIAL CHANGES

机译：通过校正继发性线粒体变化治疗先天性结构肌病和先天性肌营养不良的方法

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FIELD: medicine.;SUBSTANCE: invention refers to medicine, particularly psychoneurology, and concerns treatment of congenital structural myopathies and muscular dystrophies. That is ensure by the energotropic therapy consisting in the administration of L-carnitine in dosage 20-30 mg/kg/day, coenzyme Q10 in dosage 60-90 mg/day, succinic acid - 200 mg/day, citric acid - 50 mg/kg a day, vitamin B₁ - 100 mg/kg a day, vitamin B₆ - 200 mg a day, vitamin B₁₂ - 200 mg/day for two months two times with an interval of two months.;EFFECT: such complex of drug therapy including the administration of coenzyme Q10 in high dose combined with the developed regimen provides motion activity increase in children suffering structural myopathies and congenital muscular dystrophies due to the integrated effect on various links of mitochondrial exchange.;2 ex, 7 dwg

机译：技术领域本发明涉及医学，特别是心理神经学，并且涉及先天性结构性肌病和肌肉营养不良的治疗。这是通过能量疗法来确保的，该疗法包括以20-30 mg / kg /天的剂量施用L-肉碱，以60-90 mg /天的剂量施用辅酶Q10，以200毫克/天的琥珀酸，以50 mg的柠檬酸的形式/ kg每天，维生素B _{1 -每天100 mg / kg，维生素B _{6 -每天200 mg，维生素B _{12 - 200毫克/天，连续两个月，两次，间隔两个月。效果：这种复杂的药物治疗包括高剂量辅酶Q10的给药与已开发的方案相结合，可增加患有结构性肌病和先天性肌病的儿童的运动活动由于对线粒体交换各个环节的综合影响而引起营养不良。; 2 ex，7 dwg}}}

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公开/公告号RU2400221C2

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公开/公告日2010-09-27

原文格式PDF
申请/专利权人 FGU MOSKOVSKIJ NII PEDIATRII I DETSKOJ KHIRURGIIROSMEDTEKHNOLOGIJ;
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申请/专利号RU20080144610
发明设计人 BELOUSOVA ELENA DMITRIEVNA;KHARLAMOV DMITRIJ ALEKSEEVICH;VLODAVETS DMITRIJ VLADIMIROVICH;SUKHORUKOV VLADIMIR SERGEEVICH;
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申请日2008-11-11
分类号A61K31/122;A61K31/194;A61K31/205;A61P21/04;
国家 RU
入库时间 2022-08-21 18:29:29

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