首页> 外国专利> STRAIN 'VNIIZZH 2003' OF GOAT-POX VIRUS VARIOLA VIRUS CAPRINUM TO PRODUCE BIOPREPARATIONS FOR DIAGNOSTICS AND SPECIFIC PROPHYLACTICS OF GOAT-POX

STRAIN 'VNIIZZH 2003' OF GOAT-POX VIRUS VARIOLA VIRUS CAPRINUM TO PRODUCE BIOPREPARATIONS FOR DIAGNOSTICS AND SPECIFIC PROPHYLACTICS OF GOAT-POX

机译：山羊痘病毒变种变种冠状病毒的“ VNIIZZH 2003”菌株产生了山羊痘的诊断和特殊预防性生物制剂

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FIELD: veterinary science.;SUBSTANCE: new production strain "VNIIZZh 2003" of goat-pox virus (VOK) has been produced, which is attenuated and avirulent for goats. Strain is deposited into collection of microorganisms used in veterinary science and livestock sector of FGU "VGNKI" under the following registration number - production vaccine strain "VNIIZZh 2003" - DEP VOK. Strain is reproduced in primary culture of goat gonad cells Ch-91 for 5-7 days and is accumulated in titre of at least 5.5 lg TCD₅₀/cm³. Strain preserves original characteristics during passage in culture of Ch-91 cells for 35 passages. Strain has served as the basis to make antigen for serological reactions and hyperimmune blood serums to VOK in rabbits and goads with activity in RDSK 1:120-1:160, in RDP 1:16-1:32 and in IFA 1:1000-1:4000. Virus vaccine produced on the basis of strain protects immunised animals against direct infection with virulent virus.;EFFECT: expanded arsenal of production VOK strains and possibility to use them in veterinary medicine.;3 cl, 4 dwg, 9 tbl, 12 ex

机译：领域：兽医科学;物质：山羊痘病毒（VOK）的新生产菌株“ VNIIZZh 2003”已生产，对山羊减毒无毒。菌株以以下注册号存放在FGU“ VGNKI”的兽医学和畜牧业部门使用的微生物中：生产疫苗菌株“ VNIIZZh 2003”-DEVOK。菌株在山羊性腺细胞Ch-91的原代培养物中繁殖5-7天，并以至少5.5 lg TCD _{50 / cm ^{3 的滴度积累。在传代Ch-91细胞35次的过程中，菌株保留了原始特征。菌株已成为在兔和山羊中产生血清学反应和超免疫血清针对VOK的抗原的基础，并在RDSK 1：120-1：160，RDP 1：16-1：32和IFA 1：1000-中具有活性1：4000。以毒株为基础生产的病毒疫苗可保护免疫动物免受强毒病毒的直接感染。效果：扩大了生产的VOK毒株的库，并有可能在兽医学中使用它们; 3 cl，4 dwg，9 tbl，12 ex}}

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公开/公告号RU2389791C1

专利类型
公开/公告日2010-05-20

原文格式PDF
申请/专利权人 FEDERALNOE GOSUDARSTVENNOE UCHREZHDENIE FEDERALNYJ TSENTR OKHRANY ZDOROVJA ZHIVOTNYKH (FGU VNIIZZH);
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申请/专利号RU20080136310
发明设计人 DIEV VJACHESLAV IVANOVICH;MOROZ NATALJA VLADIMIROVNA;BASOVA DARJA KONSTANTINOVNA;BLOTOVA GALINA ALEKSANDROVNA;KUKUSHKINA MARIJA SERGEEVNA;GARKIN ALEKSEJ VIKTOROVICH;BORISOV VLADIMIR VLADIMIROVICH;SHCHERBAKOV ALEKSEJ VLADIMIROVICH;ORLOVA ELENA SERGEEVNA;KONSTANTINOV ALEKSEJ VLADIMIROVICH;JASNEVA ELENA ANATOLEVNA;ZAKHAROV VALERIJ MIKHAJLOVICH;
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申请日2008-09-08
分类号C12N7;
国家 RU
入库时间 2022-08-21 18:29:41

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