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首页> 外国专利> BIOTRANSPLANT BASED ON FOAMED CERAMIC CARRIERS OF ZIRCONIUM OXIDE AND ALUMINIUM OXIDE SYSTEM AND MULTIPOTENT STROMAL CELLS OF HUMAN BONE MARROW FOR RESTORING EXTENDED BONE TISSUE DEFECTS AND METHOD FOR MAKING THEREOF

BIOTRANSPLANT BASED ON FOAMED CERAMIC CARRIERS OF ZIRCONIUM OXIDE AND ALUMINIUM OXIDE SYSTEM AND MULTIPOTENT STROMAL CELLS OF HUMAN BONE MARROW FOR RESTORING EXTENDED BONE TISSUE DEFECTS AND METHOD FOR MAKING THEREOF

机译：基于氧化锆和氧化铝的陶瓷陶瓷载体和人骨髓多能基质细胞的生物移植物用于修复扩展的骨组织缺损及其修复方法

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FIELD: medicine.;SUBSTANCE: invention refers to medicine and represents a biotransplant based on a high-porous ceramic material of zirconium oxide - aluminium oxide system and multipotent stromal cells of human bone marrow for restoring the extended bone tissue defects characterised by that contains autologous or donor multipotent mesenchimal stromal cells (MMSC) of bone marrow and a carrier made of the high-porous ceramic material of zirconium oxide - aluminium oxide system by polyurethane foam base doubling with the carrier being densely seeded with MMSC cultivated within 1 to 3 passages; one carrier contains 200 to 500 thousand cells immobilised of the vitality at least 90%, while the functional targeting is verified by the ability to the directed differentiation of the mesodermal lines and the expression of stromal markers CD90 and CD105 in 60 - 90% of cells and the absence of expression of marker CD34 is shown.;EFFECT: invention provides accelerated repair processes and more effective osteointegration.;5 cl
机译：领域：药物：发明是指药物，代表了一种基于氧化锆-氧化铝系统的高孔陶瓷材料和人骨髓多能基质细胞的生物移植，该生物移植物的特征在于含有自体的或骨髓供体多能间充质基质细胞（MMSC）和由氧化锆-氧化铝系统的高孔陶瓷材料制成的载体，通过聚氨酯泡沫基底加倍，并在1-3代内培养的MMSC密集接种该载体;一种载体包含200至500,000个细胞，其活力至少90％被固定，而功能靶向则通过中皮系定向分化的能力以及60- 90％细胞中基质标志物CD90和CD105的表达来验证效果：本发明提供了加速的修复过程和更有效的骨整合。5 cl

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