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TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE LUNG DISEASES USING TRIPLE COMBINATIONS
TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE LUNG DISEASES USING TRIPLE COMBINATIONS
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机译：三联疗法治疗哮喘和慢性阻塞性肺疾病
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摘要
1. A medicament comprising, individually or in a mixture (A), a compound of formula I! ! in free form or in salt form or in solvate form,! where W is a group of the formula! ! Rx and Ry both mean -CH2- or - (CH2) -,! R1 is hydrogen, hydroxy or C1-C10 alkoxy! R2 and R3 each independently mean hydrogen or C1-C10 alkyl,! R4, R5, R6 and R7 each independently mean hydrogen, halogen, cyano, hydroxy,! C1-C10 alkoxy, C6-C10 aryl, C1-C10 alkyl, C1-C10 alkyl substituted with one or more halogen atoms or one or more hydroxy or C1-C10 alkoxy groups; C1-C10 alkyl interrupted by one or more heteroatoms, C2-C10 alkenyl, trialkylsilyl, carboxy, C1-C10 alkoxycarbonyl or -CONR11R12, where R11 and R12 each independently mean hydrogen or C1-C10 alkyl,! or R4 and R5, R5 and R6, or R and R together with the carbon atoms to which they are attached form a 5-, 6- or 7-membered carbocyclic ring or a 4-10-membered heterocyclic ring, and! R8, R9 and R10 each independently mean hydrogen or C1-C4 alkyl,! (B) glycopyrronium salt and! (C) Mometasone furoate,! intended for simultaneous, sequential or separate administration in the treatment of inflammatory or obstructive airway disease. ! 2. The drug according to claim 1, which means a pharmaceutical composition comprising a mixture of effective amounts of compounds (A), (B) and (C) optionally in a mixture with at least one pharmaceutically acceptable carrier. ! 3. The drug according to claim 1, where (A) means a compound of formula I in free form, or in salt form, or in the form of a solvate, where R8, R9 and R10 each means H, R1 means OH, R2 and R3 each means H, and! (1) Rx and Ry both mean -CH2-, R4 and R7 each mean CH3O-, and R5 and
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