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MEDICINE FOR PROTECTION OF MOTOR NEURON IN PATIENTS WITH LATERAL AMYOTROPHIC SCLEROSIS

机译：侧索肌萎缩症患者的运动神经元保护药物

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1. An agent for protecting a motor neuron in patients with amyotrophic lateral sclerosis, which contains a combination of (a) (2R) -2-propyloctanoic acid or its salt and (b) a drug for amyotrophic lateral sclerosis. ! 2. The tool according to claim 1, which is used to suppress muscle weakness. ! 3. The tool according to claim 2, which is used to suppress respiratory failure. ! 4. The tool according to claim 2, which is used to lengthen the survival period. ! 5. The tool according to claim 1, which is administered orally. ! 6. The tool according to claim 1, where the drug for amyotrophic lateral sclerosis is riluzole. ! 7. The tool according to claim 6, where the amount of riluzole is 50 mg per dose. ! 8. The tool according to claim 1, where the amount of the dose of (2R) -2-propyloctanoic acid or its salt is from 300 to 2400 mg in terms of (2R) -2-propyloctanoic acid. ! 9. The tool according to claim 8, where the amount of the dose of (2R) -2-propyloctanoic acid or its salt is 300 mg, 600 mg, 900 mg, 1200 mg, 1500 mg, 1800 mg, 2100 mg or 2400 mg, translated into ( 2R) -2-propyloctanoic acid. ! 10. The tool according to claim 9, where the amount of the dose of (2R) -2-propyloctanoic acid or its salt is 1200 mg in terms of (2R) -2-propyloctanoic acid. ! 11. The tool according to claim 6, where the amount of dose per day of (2R) -2-propyloctanoic acid or its salt is from 1200 to 2400 mg in terms of (2R) -2-propyloctanoic acid, and the amount of riluzole per day is from 50 up to 200 mg. ! 12. The tool according to claim 11, where the number of daily doses of (2R) -2-propyloctanoic acid or its salt is from one to two and the number of daily doses of riluzole is from one to four times. ! 13. Means for protecting the motor neuron in a patient with amyotrophic lateral sclerosis, which

机译：1.一种用于保护肌萎缩性侧索硬化患者的运动神经元的药物，其包含（a）（2R）-2-丙基辛酸或其盐与（b）肌萎缩性侧索硬化的药物的组合。！ 2.根据权利要求1所述的工具，其用于抑制肌肉无力。！ 3.根据权利要求2所述的工具，其用于抑制呼吸衰竭。！ 4.根据权利要求2所述的工具，其用于延长所述生存期。！ 5.根据权利要求1所述的工具，其被口服施用。！ 6.根据权利要求1所述的工具，其中用于肌萎缩性侧索硬化的药物是利鲁唑。！ 7.根据权利要求6的工具，其中利鲁唑的量为每剂50mg。！ 8.根据权利要求1所述的工具，其中，就（2R）-2-丙基辛酸而言，（2R）-2-丙基辛酸或其盐的剂量为300至2400mg。！ 9.根据权利要求8所述的工具，其中，（2R）-2-丙基辛酸或其盐的剂量为300mg，600mg，900mg，1200mg，1500mg，1800mg，2100mg或2400。毫克，翻译成（2R）-2-丙基辛酸。！ 10.根据权利要求9所述的工具，其中以（2R）-2-丙基辛酸计，（2R）-2-丙基辛酸或其盐的剂量为1200mg。！ 11.根据权利要求6所述的工具，其中，以（2R）-2-丙基辛酸计，（2R）-2-丙基辛酸或其盐的日剂量为1200〜2400mg，每天利鲁唑从50到200毫克不等。！ 12.根据权利要求11所述的工具，其中，（2R）-2-丙基辛酸或其盐的日剂量为一至两次，而利鲁唑的日剂量为一至四倍。！ 13.保护肌萎缩性侧索硬化患者运动神经元的方法，

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公开/公告号RU2008119454A

专利类型
公开/公告日2009-11-27

原文格式PDF
申请/专利权人 ОНО ФАРМАСЬЮТИКАЛ КО. ЛТД. (JP);
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申请/专利号RU20080119454
发明设计人 НИСИИ МИКИО (JP);ФУНАКОСИ ЙОСУКЕ (JP);ИМАГАВА МАСАЮКИ (JP);АБЕ СИНИТИРО (JP);КУВАЯМА ТОМОХИРО (JP);
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申请日2006-10-17
分类号A61K31/20;
国家 RU
入库时间 2022-08-21 18:30:20

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