首页>
外国专利>
A DISEASE TARGETED PEPTIDE-CONJUGATED AMPHIPHILIC CHITOSAN BASED NANOPARTICLE IMAGING AGENT FOR DIAGNOSIS OF DISEASE
A DISEASE TARGETED PEPTIDE-CONJUGATED AMPHIPHILIC CHITOSAN BASED NANOPARTICLE IMAGING AGENT FOR DIAGNOSIS OF DISEASE
展开▼
机译：一种疾病靶向肽结合的两亲性壳聚糖的纳米颗粒成像剂，用于疾病诊断
展开▼
页面导航
摘要
著录项
相似文献
摘要
PURPOSE: A nanoparticle contrast media in which fluorescence and disease target peptide are conjugated to an amphiphilic chitosan derivative is provided to improve targeting efficiency and increase efficiency of preventing and treating diseases. CONSTITUTION: An amphiphilic chitosan nanoparticle contrast media has fluorescence and disease target peptide which are conjugated to bile acid derivative or fatty acid derivative. The disease target peptide is IL-4 receptor target peptide or derivative thereof; a target peptide of apoptotic cell comprising an amino acid of sequence number 2 or derivative thereof; a target peptide of bladder cancer comprising an amino acid of sequence number 3 or derivative thereof; a peptide having a peptide RGD sequence targeting aptamer, folic acid, and integrin; or transferring or derivative thereof. The peptide having a peptide RGD sequence targeting integrin is cyclo (Arg-Gly-Asp-D-Phe-Val), cyclo(Arg-Gly-Asp-D-Phe-Lys), cyclo(Arg-Gly-Asp-D-Phe-Cys), cyclo(Arg-Gly-Asp-D-Phe-Glu), cyclo(Arg-Gly-Asp-D-Tyr-Lys), cyclo(Arg-Gly-Asp-D-Tyr-Glu), Arg-Gly-Asp-Ser or Gly-Arg-Gly-Asp-Ser. A contrast medium contains radioactive isotope, quantum dot or MRI contrast media.
展开▼
