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BIFUNCTIONAL FUSION PROTEINS OF THE ALPHA-MELANOCYTE STIMULATING HORMONE (ALPHA-MSH) AND ATRIAL NATRIURETIC PROTEIN (ANP) AND USES IN HYPERTENSION AND ACUTE KIDNEY INJURY
BIFUNCTIONAL FUSION PROTEINS OF THE ALPHA-MELANOCYTE STIMULATING HORMONE (ALPHA-MSH) AND ATRIAL NATRIURETIC PROTEIN (ANP) AND USES IN HYPERTENSION AND ACUTE KIDNEY INJURY
A bifunctional hormone exhibiting an alpha-MSH activity and a natriuretic peptide activity is described. The bifunctional hormone comprises for example a first domain having alpha-MSH related hormonal activity covalently linked to a second domain having natriuretic peptide related hormonal activity. The bifunctional hormone of the present invention is useful for example for the prevention and/or treatment of renal related diseases or conditions, such as acute renal failure (ARF) or acute kidney injury (AKI).
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