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HUMAN ANTIBODIES THAT BIND HUMAN TNF ALPHA

机译:结合人类肿瘤坏死因子甲的人类抗体

摘要

The invention relates to a recombinant human antibody that binds to the human tumour necrosis factor (hTNF alpha) which has affinity to hTNF alpha, Kd=10-8M or less and an off-rate constant koff of 1x10-3s -1 or less and neutralizes the activity in vitro and in vivo, and to a nucleic acid encoding the same, the host cell comprising a recombinant expression vector, and to a pharmaceutical composition comprising said antibody, administered for treating disorders in which the TNF alpha activity is detrimental.
机译:本发明涉及与人肿瘤坏死因子(hTNFα)结合的重组人抗体,所述人肿瘤坏死因子对hTNFα具有亲和力,Kd = 10-8M或更低,并且失活率恒定koff为1x10-3s -1或更低,并且在体内和体外中和活性,并对其编码的核酸,包含重组表达载体的宿主细胞,和对包含所述抗体的药物组合物进行中和,所述药物组合物被施用以治疗其中TNFα活性有害的疾病。

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