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identification of hla-a2 t-cell epitopes derived from immature oncofetal antigen laminin receptor protein and uses thereof
identification of hla-a2 t-cell epitopes derived from immature oncofetal antigen laminin receptor protein and uses thereof
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机译:源于未成熟胎胚抗原层粘连蛋白受体蛋白的hla-a2 t细胞表位的鉴定及其用途
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摘要
Identification of T-cell epitopes presented by HLA-A2 derived from the laminae receptor protein immature of the oncofetal antigen and their use. The present invention relates to immunotherapeutic methods and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to cancer immunotherapy, in particular to various tumor entities, including malignant hematologic diseases. The present invention also relates to tumor-associated T-helper peptide epitopes, alone or in combination with other tumor-associated peptides, which serve as active pharmaceutical ingredients in antitumor immune response stimulating vaccine compositions. In particular, the present invention relates to two novel peptide sequences derived from oncofetal antigen immature laminin receptor (OFA / iLR) HLA class I or II molecules usable in vaccine compositions to elicit anti-tumor immune responses.
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