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IDENTIFICATION OF HLA-A2 PRESENTED T-CELL EPITOPES DERIVED FROM THE ONCOFETAL ANTIGEN-IMMATURE LAMININ RECEPTOR PROTEIN AND USES THEREOF
IDENTIFICATION OF HLA-A2 PRESENTED T-CELL EPITOPES DERIVED FROM THE ONCOFETAL ANTIGEN-IMMATURE LAMININ RECEPTOR PROTEIN AND USES THEREOF
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机译：致癌抗原不成熟层粘连蛋白受体蛋白衍生的HLA-A2阳性T细胞表位的鉴定及其用途
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摘要
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular several tumor entities including hematological malignancies. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the present invention relates to two novel peptide sequences derived from HLA class I or Il molecules of human oncofoetal antigen immature laminin receptor (OFA/iLR) which can be used in vaccine compositions for eliciting anti-tumor immune responses.
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