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MODULATION OF NITRIC OXIDE SIGNALING TO NORMALIZE TUMOR VASCULATURE
MODULATION OF NITRIC OXIDE SIGNALING TO NORMALIZE TUMOR VASCULATURE
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机译:调节一氧化氮信号以使肿瘤血管正常化
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摘要
The instant invention provides methods for treating a solid tumor in a subject comprising modulating nitric oxide production in the tumor to normalize tumor vasculature and administering an anti-tumor therapy to the subject. The invention further provides methods of treating a solid tumor in a subject comprising selectively increasing cyclic guanosine monophosphate (cGMP) or cGMP dependent protein kinase G production in the tumor vasculature to an amount effective to normalize tumor vasculature and administering an anti-tumor therapy to the subject.
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