首页> 外国专利> MULTI-PHASIC PHARMACEUTICAL FORMULATIONS OF POORLY WATER-SOLUBLE DRUGS FOR REDUCED FED/FASTED VARIABILITY AND IMPROVED ORAL BIOAVAILABILITY

MULTI-PHASIC PHARMACEUTICAL FORMULATIONS OF POORLY WATER-SOLUBLE DRUGS FOR REDUCED FED/FASTED VARIABILITY AND IMPROVED ORAL BIOAVAILABILITY

机译：水溶性较差的药物的多种药物配方，可降低进食/空腹变异性和改善口服生物利用度

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摘要

Pharmaceutical formulations are disclosed comprising a multi-phasic pharmaceutical composition comprising an active pharmaceutical ingredient, wherein the active pharmaceutical ingredient is in a particulate state, a solubilized state, or in both a particulate state and in a solubilized state; a solvent; a non-miscible liquid; a stabilizer, and water; wherein the pharmaceutical formulation is an oral dosage form. Such pharmaceutical formulations are capable of reducing the fed/fast variability and improving oral bioavailability to which a number of active pharmaceutical ingredients are susceptible. The pharmaceutical formulations of the invention, therefore are bioequivalent in fed and fasted states and improved oral bioavailability.

机译：公开了包含多相药物组合物的药物制剂，所述多相药物组合物包含活性药物成分，其中所述活性药物成分处于颗粒状态，溶解状态或处于颗粒状态和溶解状态两者;溶剂不可混溶的液体;稳定剂和水;其中药物制剂是口服剂型。这样的药物制剂能够减少进食/快速变化并改善许多活性药物成分易感的口服生物利用度。因此，本发明的药物制剂在进食和禁食状态下是生物等效的，并且口服生物利用度得到改善。

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公开/公告号US2010143420A1

专利类型
公开/公告日2010-06-10

原文格式PDF
申请/专利权人 DINESH SHENOY;ROBERT LEE;
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申请/专利号US20080523445
发明设计人 DINESH SHENOY;ROBERT LEE;
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申请日2008-01-22
分类号A61K38/12;A61P1/08;A61P9;A61P25;A61P21/02;A61P7/02;A61K31/216;A61K31/436;A61K31/58;A61K31/192;A61K31/496;A61K31/343;A61K31/5377;A61K9/14;
国家 US
入库时间 2022-08-21 18:52:44

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