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Protein carrying calcium phosphate, its production method and protein slow release body using the same, artificial bone and tissue engineering scaffolds
Protein carrying calcium phosphate, its production method and protein slow release body using the same, artificial bone and tissue engineering scaffolds
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机译：携带磷酸钙的蛋白质，其生产方法和使用该蛋白质的缓慢释放体，人造骨和组织工程支架
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摘要
It is intended to provide sintered calcium phosphate carrying a protein which has a high biocompatibility with a drug to be used, by which the protein can be strongly carried in an increased amount owing to enhanced calcium phosphate deposition and which can sustainedly release the protein over a prolonged period of time. Sintered calcium phosphate wherein, using a persaturated solution of unstable calcium phosphate containing a protein capable of undergoing spontaneous nucleation, the period of time until the spontaneous nucleation is artificially controlled so that coprecipitation/deposition on a calcium phosphate substrate is completed before the spontaneous nucleation of the whole solution, or the spontaneous nucleation is effected exclusively around the substrate to thereby increase the amount of the deposited calcium phosphate, thereby increasing the amount of the protein carried thereon.
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