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Detection of somatic mutations in mitochondrial DNA determine the effects of anti-cancer agents
Detection of somatic mutations in mitochondrial DNA determine the effects of anti-cancer agents
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机译:线粒体DNA中体细胞突变的检测决定了抗癌药的作用
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摘要
PROBLEM TO BE SOLVED: To provide a method for discriminating anticancer agent sensitivity of a specimen by using mutation of a mitochondria gene of a specimen as an index and a kit for discriminating anticancer agent sensitivity of the specimen.;SOLUTION: The method for measuring sensitivity of a cell containing a mitochondria DNA of mutation type to an anticancer agent comprises fusing an enucleated cell containing the mitochondria DNA of mutation type with a mitochondria DNA-deficient cell to give a cybrid, culturing the cybrid in the presence of the anticancer agent and assaying the cybrid that caused apoptosis.;COPYRIGHT: (C)2005,JPO&NCIPI
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