首页> 外国专利> U.S. Provisional Patent Application No. 60 / 923,086 discloses microfluidic radiosynthesis system for positron emission tomography biomarkers RELATED APPLICATIONS This application, April 2007 which was filed on April 12, 2007 United States non-provisional patent application No. 11 / 895,636 discloses, and 2008 1, which was filed United States Provisional Patent Application No. 60 / No. 923,407, filed on the 13th month, on August 23, 2007 This application claims priority based on U.S. Provisional Patent Application No. 61 / 010,822 discloses, filed on the 11th month, the contents of each of which are incorporated herein by reference in its entirety.

U.S. Provisional Patent Application No. 60 / 923,086 discloses microfluidic radiosynthesis system for positron emission tomography biomarkers RELATED APPLICATIONS This application, April 2007 which was filed on April 12, 2007 United States non-provisional patent application No. 11 / 895,636 discloses, and 2008 1, which was filed United States Provisional Patent Application No. 60 / No. 923,407, filed on the 13th month, on August 23, 2007 This application claims priority based on U.S. Provisional Patent Application No. 61 / 010,822 discloses, filed on the 11th month, the contents of each of which are incorporated herein by reference in its entirety.

机译：美国临时专利申请第60 / 923,086号公开了用于正电子发射断层扫描生物标记物的微流体放射合成系统相关申请此申请于2007年4月，于2007年4月12日提交，美国非临时专利申请第11 / 895,636号公开，并且2008年1月，其在2007年8月23日提交的美国临时专利申请60 / 923,407的优先权本申请要求基于11月提交的美国临时专利申请61 / 010,822的优先权，其全部内容通过引用整体并入本文。

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摘要

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

机译：公开了用于以快速，有效和紧凑的方式全自动合成用于成像的放射性化合物的方法和装置，所述成像例如通过正电子发射断层摄影（PET）进行。特别地，本发明的各种实施方案提供了在微流体装置上的整个放射合成循环的自动化，独立，免提操作，其中无限制的气体流经反应器，从目标水开始并在反应器内产生纯化的PET放射性示踪剂。时间比传统化学系统短。因此，本发明的一个方面涉及一种用于放射性合成放射性标记化合物的微流体芯片，其包括反应室，连接至反应室的一个或多个流动通道，连接至所述反应室的一个或多个通风口，以及一个或多个。更多的集成阀以实现进出所述反应室的流量控制。

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公开/公告号JP2010531295A

专利类型
公开/公告日2010-09-24

原文格式PDF
申请/专利权人シーメンスメディカルソリューションズユーエスエーインコーポレイテッド;
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申请/专利号JP20100503277
发明设计人エリツァロフ、アルカディエム;ボール、キャロルエドワード;ツァン、ジャンホン;コルプ、ハルトムート;ヴァンダム、アールマイケル;ダイナー、ローレンス;フォード、シーン;ミラグハイエ、レザ;
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申请日2008-04-14
分类号C07H1;G01T1/161;G01N37;C07H5/02;A61K49;B01J19;
国家 JP
入库时间 2022-08-21 19:01:51

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