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Preventive treatment of patients with mild cognitive disorders, which based on increase of circulation-relevant peptide-biomarker measurable in circulation, with medicament comprising e.g. angiotensin converting enzyme-inhibitor
Preventive treatment of patients with mild cognitive disorders, which based on increase of circulation-relevant peptide-biomarker measurable in circulation, with medicament comprising e.g. angiotensin converting enzyme-inhibitor
Method for preventive treatment of patients with mild cognitive disorders, which based on increase of circulation-relevant peptide-biomarker measurable in its circulation are identifiable as the patients having a increased risk of developing a clinically manifest Alzheimer dementia, with medicaments, is claimed, where the medicaments comprise one or more active agents of cardiovascular preparations including angiotensin converting enzyme-inhibitor, angiotensin-II-receptor antagonist, beta blocker and/or antihypersensitive diuretics. An independent claim is included for an in vitro method for determining therapy requiring patients with mild cognitive disorders for which an increased risk for deterioration of primary mild cognitive disorder and for developing clinical manifest neurodegenerative diseases of type Alzheimer dementia, comprising: determining at least one circulation-relevant peptide-biomarkers in a biological liquid sample obtained from the circulation of the patient, who has been diagnosed with mild cognitive diseases; correlating a concentration for at least one peptide biomarkers, which lie over a biomarker specific threshold (cut-off) value in the area of the usual concentration values for the biomarkers in mild cognitive disorder, an increased risk for developing clinical manifest neurodegenerative diseases of type Alzheimer dementia; and recommending for treatment with delivery of the cardiovascular preparations to the patients with the assessed increased risk. ACTIVITY : Nootropic; Neuroprotective. MECHANISM OF ACTION : Angiotensin converting enzyme-inhibitor; Angiotensin-II-receptor antagonist; Beta blocker.
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