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TARGETING OF ALPHA-1 OR ALPHA-3 SUBUNIT OF NA+, K+-ATPASE IN THE TREATMENT OF PROLIFERATIVE DISEASES

机译：NA +，K + -ATPase的Alpha-1或Alpha-3亚基在治疗增生性疾病中的作用

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摘要

Targeting of select subunits of the Na+,K+-ATPase is described, and especially the alpha-1 subunit and/or the alpha-3 subunit. Antisense agents, agents capable of causing RNA interference that can reduce the expression of Na+,K+-ATPase, and antibodies and antibody fragments and derivatives specific for Na+,K+-ATPase are useful as reagents and pharmaceutical formulations for the treatment of proliferative diseases, such as tumours and cancers. Methods and kits are also described.

机译：描述了靶向Na +，K + -ATP酶的选择亚基，尤其是α-1亚基和/或α-3亚基。反义剂，能够引起RNA干扰的可降低Na +，K + -ATP酶表达的试剂，以及对Na +，K + -ATP酶特异的抗体和抗体片段以及衍生物，可用作治疗增生性疾病的试剂和药物制剂，例如作为肿瘤和癌症。还介绍了方法和试剂盒。

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公开/公告号EP2087112A1

专利类型
公开/公告日2009-08-12

原文格式PDF
申请/专利权人 UNIBIOSCREEN S.A.;
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申请/专利号EP20060828976
发明设计人 MIJATOVIC TATJANA;VAN QUAQUEBEKE ERIC;DENÈVE NANCY;VAN DEN HOVE LAURENT;DARRO FRANCIS;KISS ROBERT;
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申请日2006-11-09
分类号C12N15/11;A61K31/429;A61P35;
国家 EP
入库时间 2022-08-21 19:15:08

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