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COMPOSITIONS AND METHODS FOR REGULATING ERYTHROPOIENTIN EXPRESSION AND AMELIORATING ANEMIA AND STIMULATING ERYTHROPOIESIS
COMPOSITIONS AND METHODS FOR REGULATING ERYTHROPOIENTIN EXPRESSION AND AMELIORATING ANEMIA AND STIMULATING ERYTHROPOIESIS
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机译：调节红细胞生成素表达和改善贫血和刺激红细胞生成的组合物和方法
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摘要
The invention provides compositions (e.g., pharmaceuticals, formulations) and methods for ameliorating (e.g., preventing or treating) an anemia and/or stimulating erythropoiesis and/or EPO erythropoietin synthesis. The invention provides compositions comprising a chimeric protein artificial transcription factor comprising a plurality of (multiple) protein DNA-binding domains, e.g., zinc finger binding domains, specific for the promoter region of an erythropoietin (EPO) gene; a consensus nuclear localization protein sequence; a cell-penetrating peptide sequence; and a transcription activation domain.
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