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NON-HUMAN TRANSGENIC MAMMAL FOR THE CONSTANT REGION OF THE CLASS A HUMAN IMMUNOGLOBULIN HEAVY CHAIN AND APPLICATIONS THEROF
NON-HUMAN TRANSGENIC MAMMAL FOR THE CONSTANT REGION OF THE CLASS A HUMAN IMMUNOGLOBULIN HEAVY CHAIN AND APPLICATIONS THEROF
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机译:A类人免疫球蛋白重链恒定区的非人类转基因哺乳动物及其应用
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摘要
Non-human transgenic animal (I) comprising an immunoglobulin (Ig) H locus modified by replacement of the commutation sequence (Smu ) by all or part of a transgene comprising the Calpha gene of a human IgA, including at least the exons that encode the CH3 domain and the membrane exon, is new. Independent claims are also included for: (1) a targeting vector (II) for homologous recombination comprising the Calpha gene (or a fragment containing at least the CH3 and membrane exons), flanked by sequences of the IgH locus adjacent to the Smu sequence; (2) embryonic cells of a non-human mammal modified by (III); (3) producing humanized IgA antibodies or their fragments; and (4) antibodies (III) produced by method of (3) and their fragments. ACTIVITY : Cytostatic; Antimicrobial. No biological data given. MECHANISM OF ACTION : Vaccine.
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