3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS

• 1. 作为蛋白激酶抑制剂的3－(4－酰氨基吡咯－2－基亚甲基)－2－二氢吲哚酮衍生物 [P] . 中国专利： CN100338059C . 2007.09.19
• 2. 作为蛋白激酶抑制剂的3－(4－酰氨基吡咯－2－基亚甲基)－2－二氢吲哚酮衍生物 [P] . 中国专利： CN1529704A . 2004-09-15
• 3. 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors [P] . 美国专利： US8158656B2 . 2012-04-17

  机译： 2-茚满酮衍生物作为多靶蛋白激酶抑制剂和组蛋白脱乙酰基酶抑制剂

• 4. 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS [P] . 美国专利： US2009298886A1 . 2009-12-03

  机译： 2-吲哚酮衍生物作为多靶点蛋白激酶抑制剂和组蛋白去乙酰化抑制剂

• 5. 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS [P] . RS51026B . 2010-10-31

  机译： 3-（4-酰胺基吡咯-2-基甲基）-2-吲哚啉酮衍生物作为蛋白激酶抑制剂

• 1. Design of Chimeric Histone Deacetylase- and Tyrosine Kinase-Inhibitors: A Series of Imatinib Hybrides as Potent Inhibitors of Wild-Type and Mutant BCR-ABL, PDGF-Rβ, and Histone Deacetylases [J] . Siavosh Mahboobi, Stefan Dove, Andreas Sellmer, Journal of Medicinal Chemistry . 2009,第8期
• 2. (-)-Epigallocatechin 3-gallate inhibits invasion by inducing the expression of Raf kinase inhibitor protein in AsPC?1 human pancreatic adenocarcinoma cells through the modulation of histone deacetylase activity [J] . Sung Ok Kim, Mi Ryeo Kim International journal of oncology . 2012,第1期
• 3. Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C) [J] . Justin B. Maxhimer, Rishindra M. Reddy, Jingtong Zuo, The journal of thoracic and cardiovascular surgery . 2005,第1期
• 4. Synthesis, Evaluation and Molecular Modeling Study of L-2-amino-7/8-Bromoalkanoic Acid Derivatives as Histone Deacetylase Inhibitors [C] . Dawei Huang, Xiaohui Li, Zhilong Xiu, Chinese international peptide symposium . 2011
• 5. Syntheses and biological evaluation of polyamine derivatives as histone deacetylase inhibitors. [D] . Varghese, Sheeba. 2006
• 6. Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells [O] . Rayna Rosati, Bailing Chen, Mugdha Patki, -1
• 7. (-)-Epigallocatechin 3-gallate inhibits invasion by inducing the expression of Raf kinase inhibitor protein in AsPC-1 human pancreatic adenocarcinoma cells through the modulation of histone deacetylase activity [O] . SUNG OK KIM, MI RYEO KIM 2012

• 1. Prolonged Disease Stabilization and Tolerability in a Nuclear Protein in Testis Midline Carcinoma Patient Treated with Dual Histone Deacetylase and Phosphoinositide 3-Kinase Inhibitor CUDC-907 [J] . Pamela Munster ,Nilson Wu ,Meaghan McMahon . 临床医学病理报告（英文） . 2018,第7期
• 2. Evaluation of the Antitumor and Radiosynthetizing Activity of a Novel Quinoline Sulfonamide Derivative (PIQSA) as a Histone Deacetylase Inhibitor [J] . Eman Noaman ,Nadia Fahmy ,Raafat Yousri . 癌症治疗（英文） . 2011,第4期
• 3. Induction of Myelogenous Leukemia Cells with Histone Deacetylase Inhibitors through Down-regulating the Daxx Protein Expression [J] . Chunrui LI ,Jianfeng ZHOU ,Xueqiong WU . 华中科技大学学报（医学）（英德文版） . 2009,第005期
• 4. Induction of Myelogenous Leukemia Cells with Histone Deacetylase Inhibitors through Down-regulating the Daxx Protein Expression [J] . 李春蕊 ,周剑峰 ,吴雪琼 . 华中科技大学学报：医学英德文版 . 2009,第005期
• 5. Drug repurposing of histone deacetylase inhibitors that alleviate neutrophilic inflammation in acute lung injury and idiopathic pulmonary fibrosis via inhibiting leukotriene a4 hydrolase and blocking LTB4 biosynthesis [J] . Wei-qiang LU ,Jing-yuan WANG ,Xue YAO . 中国药理学与毒理学杂志 . 2017,第010期
• 6. 4-取代的2-(2-氟-3-三氟甲基苯基)-1,3,4-噁二嗪-5-酮衍生物的合成及其生物活性 [C] . 袁莉萍 ,曹瑾 ,陈亮 . 第八届全国新农药创制学术交流会 . 2009
• 7. 3-酰胺基-4-吲哚马来酰亚胺类蛋白激酶C抑制剂的合成及抗肿瘤活性研究 [A] . 牟世伟 . 2007