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BIOMIMETIC ORGANIC/INORGANIC COMPOSITES, PROCESSES FOR THEIR PRODUCTION, AND METHODS OF USE

机译：生物有机/无机复合材料，其生产过程及其使用方法

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摘要

The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.

机译：本发明涉及一种复合物，该复合物包括有机流体可溶胀的纤维基质（例如胶原蛋白）和矿物质相（例如碳酸钙或磷酸盐矿物质相），用作骨的仿生物。在另一方面，本发明涉及一种制备复合物的方法，该方法包括将酸性聚合物包含到过饱和的矿化溶液中，以诱导无机矿物质的无定形液相前体，然后将其吸收（通过毛细作用拉扯）。）放入有机基质中。有利地，一旦固化，就可以实现高矿物质含量，其中无机矿物质晶体嵌入胶原纤维内（纤颤地）并定向，使得它们沿着有机基质纤维的长轴排列，从而紧密地模仿天然骨骼的结构。本发明还涉及通过将仿生复合物施加到骨缺损部位来治疗患有骨缺损的患者的方法。

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公开/公告号WO2005081699A3

专利类型
公开/公告日2009-04-16

原文格式PDF
申请/专利权人 UNIVERSITY OF FLORIDA;GOWER LAURIE B.;OLSZTA MATTHEW J.;DOUGLAS ELLIOT P.;MUNISAMY SIVAKUMAR;WHEELER DONNA L.;
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申请/专利号WO2004US33737
发明设计人 OLSZTA MATTHEW J.;MUNISAMY SIVAKUMAR;GOWER LAURIE B.;WHEELER DONNA L.;DOUGLAS ELLIOT P.;
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申请日2004-10-12
分类号C12N11/14;A61F2/00;A61K38/00;A61L27/24;A61L27/44;A61L27/46;A61L31/12;A61L31/14;C07K17/02;C07K17/14;C12N5/00;
国家 WO
入库时间 2022-08-21 19:22:16

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