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Production and use of variants of domain 2 of non-native bikunina Human placenta designed by directed Molecular Evolution
Production and use of variants of domain 2 of non-native bikunina Human placenta designed by directed Molecular Evolution
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机译：通过定向分子进化设计的非天然bikunina人胎盘结构域2变体的生产和使用
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摘要
Refers to hbikd2 (dominio2 non-native variants of the Kunitz type inhibitor of Human bikunina) that may occur as a functional Protein at a high level in a Yeast Secretion System while maintaining a favorable Profile of inhibition against the Serine proteases; S variants contain the Amino Acid Sequence is selected from the group consisting of SEq. 1 to SEQ ID no.. ID no. 40. It also relates to a Nucleic Acid encoding a polypeptide and that in a Pharmaceutical composition. These variants do not show a native expression Enhanced at least 2 Times compared with hbikd2 Native, besides its human origin allows the repeated use of the drug in patients with adverse immune responses.They are useful to prevent blood loss during operations with an increased bleeding Risk, terapeurica intervention in thromboembolism, Bleeding after Surgery operation
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