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Method of antigen incorporation into neisseria bacterial outer membrane vesicles and resulting vaccine formulations

机译:将抗原掺入奈瑟菌细菌外膜囊泡中的方法和所得疫苗制剂

摘要

Disclosed is a method for the insertion of protein antigens, of recombinant or synthetic origin, in outer membrane vesicles of Gram-negative bacteria without disruption of the vesicle structure, therefore maintaining the immunogenicity and immunostimulatory properties of said vesicles, and with the reported advantage that the immune response generated against the incorporated antigen is superior to the one generated when the antigen is administered alone. The resultant vaccine formulations are useful to increase protective capacity of existing vaccines and allow to extend it against different pathogens, in diseases of bacterial, viral, cancerous or other etiology. The referred formulations are applicable in the pharmaceutical industry as vaccines for therapeutic and preventive use in humans.
机译:公开了一种在革兰氏阴性细菌的外膜囊泡中插入重组或合成来源的蛋白抗原而不破坏囊泡结构的方法,因此保持了所述囊泡的免疫原性和免疫刺激特性,并且具有以下优点:对掺入的抗原产生的免疫应答优于单独给予抗原时产生的免疫应答。所得的疫苗制剂可用于提高现有疫苗的保护能力,并使其在细菌,病毒,癌性或其他病因学疾病中能够抵抗不同的病原体。所提及的制剂可作为用于人类的治疗和预防用途的疫苗用于制药工业。

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