首页> 外国专利> 3' - {N' - 1 - (3,4 - DIMETHYLPHENYL) - 3 - METHYL - 5 - OXO - 1,5 - DIHYDROPYRAZOL - 4 - YLIDENE HYDRAZINE} - 2' - HYDROXY - BIPHENYL - 3 - CARBOXYLIC ACID, 3' - {N' -1- (3,4 - DIMETHYLPHENYL) - 3 - METHYL - 5 - OXO - 1,5 - DIHYDROPYRAZOL - 4 - YLIDENE HYDRAZINE} - 2' - HYDROXY - 3' - (TETRAZOL - 5 - YL) - BIPHENYL COMPOUNDS AND THEIR DERIVATIVES AND THEIR USE IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF HEMATOPOIETIC DISORDERS

3' - {N' - 1 - (3,4 - DIMETHYLPHENYL) - 3 - METHYL - 5 - OXO - 1,5 - DIHYDROPYRAZOL - 4 - YLIDENE HYDRAZINE} - 2' - HYDROXY - BIPHENYL - 3 - CARBOXYLIC ACID, 3' - {N' -1- (3,4 - DIMETHYLPHENYL) - 3 - METHYL - 5 - OXO - 1,5 - DIHYDROPYRAZOL - 4 - YLIDENE HYDRAZINE} - 2' - HYDROXY - 3' - (TETRAZOL - 5 - YL) - BIPHENYL COMPOUNDS AND THEIR DERIVATIVES AND THEIR USE IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF HEMATOPOIETIC DISORDERS

机译：3'-{N'-[1-（3,4-二甲基苯基）-3-甲基-5-氧代-1,5-二氢吡唑-4-炔基] H]-2'-羟基-联苯-3-羧酸，3'-{N'-[1-（3,4-二甲基苯基）-3-甲基-5-氧代-1,5-二氢吡唑-4-炔基]肼}-2'-羟基-3'-（四唑-5-YL）-联苯酚化合物及其衍生物及其在制备治疗造血障碍的药物组合物中的用途

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摘要

Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

机译：发明了非肽TPO模拟物。还发明了用于制备本发明化合物的新方法和中间体。还发明了一种在有需要的哺乳动物包括人中治疗血小板减少症的方法，该方法包括向所述哺乳动物施用有效量的所选羟基-1-偶氮苯衍生物。

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公开/公告号IL152988B

专利类型
公开/公告日2009-02-11

原文格式PDF
申请/专利权人 GLAXOSMITHKLINE LLC;GLAXO GROUP LIMITED;
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申请/专利号IL152988
发明设计人
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申请日2002-11-20
分类号C07D231/46;A61K;A61K31/41;A61K31/4152;A61K31/4155;A61K31/427;A61K31/435;A61K31/4439;A61K31/455;A61K31/675;A61K38;A61K39;A61K45;A61P7;A61P7/04;A61P37/04;A61P43;C07C205/59;C07C229/64;C07C309/49;C07C311/02;C07D213/79;C07D213/80;C07D231/48;C07D257/04;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/04;C07D405/14;C07D409/04;C07D417/04;C07D417/12;
国家 IL
入库时间 2022-08-21 19:27:48

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