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首页> 外国专利> N - (2 - (hetaril arilsulfonamidas) and N - (2 - (heteraril) hetaril) arilsulfonamidas

N - (2 - (hetaril arilsulfonamidas) and N - (2 - (heteraril) hetaril) arilsulfonamidas

机译：嗯（2-（Hetari l）地狱l Fonamida s）和d Hmm（2-（Heterari l）地狱l）是l l Fonamida s

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As a CCR9 receiver, it has strong resistance. Animal experiments have shown that these compounds are effective tools for the treatment of inflammation, a unique sign of disease CCR9. These compounds, usually aril sulfonamida derivatives, can be used for pharmaceutical ingredients, methods of treating CCR9 induced diseases, and test controls to determine the target country of CCR9. Item 1: a compound, salt, or N-oxidation, characterized by its response to (1) formula, wherein AR1 is an alternative or unsubstituted arilo C6-10, or a heterogeneous arilo of 5 to 10 alternative or unsubstituted members;NR3 -SR3, - S (o) R3, - S (o) 2r3, - S (o) 2nr3, - S (o) 2nr4, arilo C6-10 substituted or unreplaced, 5-10 substituted or unreplaced isomerization, 3-10 substituted or unreplaced isomerization, a is n-cr4, X1 -- x2 -- X3 from N-N = n, C = N-N (R5),N-C (R6) 3DN N-N 3DC (R7)N-C (R6) 3DC (R7)C 3DN-C (R7)C 3DC (R6) -N (R5)R1 is a hydrogen or c1-8 tar; each R2, R3, R4, R6, and R7, when present, is selected separately from a group consisting of hydrogen, halogen, replaced or not replaced c1-8 tar, replaced or not replaced alquenilo C2-8, replaced or not replaced C2-8, replaced or not replaced C2-8 tar,-OC (O) R-Co2R-C (O) R-C (O) NR R -OC (O) NR R-NR C (O) R-NR C (O) NR R-Nr o r-NR CO2R- Sir...-S (O) R-S (O) 2R-S (O) 2NR R-NR S (O) 2R1. Arilo C6-10 replaces or does not replace, 5-10 replaces or does not replace, 3-10 replaces or does not replace isomerization; or R2 and R3, together with the atoms they replace, form 5, 6 or 7 substituted or did not replace rings; Each R5 shall be selected separately from a set of mixtures consisting of hydrogen, replaced or unreplaced c1-8, replaced or unreplaced alquenilo C2-8, replaced or unreplaced C2-8, replaced or unreplaced c2-8-bitumen.-C (O) R-C (O) NR R-S (O) R-S (O) 2R-S (O) 2NR R1. Arilo C6-10 substituted or unsubstituted, 5-10 substituted or unsubstituted, 3-10 substituted or unsubstituted isomerization; and R ',R y R son cada uno en forma independiente hidrogeno o alquilo C1-4 no sustituido o R y R junto con los tomos que sustituyen forman un anillo de 5 6 o 7 miembros sustituido o no sustituido
机译：作为CCR9接收器，它具有很强的抵抗力。动物实验表明，这些化合物是治疗炎症的有效工具，炎症是疾病CCR9的独特标志。这些化合物（通常为假种磺胺假单胞菌衍生物）可以用作药物成分，治疗CCR9诱导的疾病的方法以及测试控件，以确定CCR9的目标国家。第1项：化合物，盐或N-氧化，其特征在于其对（1）式的响应，其中AR1是替代或未取代的芳基C6-10，或5至10个替代或未取代的成员的异质芳基; NR3- SR3，-S（o）R3，-S（o）2r3，-S（o）2nr3，-S（o）2nr4，arilo C6-10取代或未取代，5-10取代或未取代的异构化，3-10取代或未取代的异构化，a为n-cr4，X1-x2-X3来自NN = n，C = NN（R5），NC（R6）3DN NN 3DC（R7）NC（R6）3DC（R7）C 3DN- C（R7）C 3DC（R6）-N（R5）R1是氢或c1-8焦油;如果存在，则每个R2，R3，R4，R6和R7分别选自氢，卤素，取代或未取代的c1-8焦油，取代或未取代的alquenilo C2-8，取代或未取代的C2 -8，已取代或未取代的C2-8焦油，-OC（O）R-Co2R-C（O）RC（O）NR R -OC（O）NR R-NR C（O）R-NR C（O ）NR R-Nr o r-NR CO2R- Sir ...- S（O）RS（O）2R-S（O）2NR R-NR S（O）2R1。 Arilo C6-10替代或不替代，5-10替代或不替代，3-10替代或不替代异构化; R2和R3与它们取代的原子一起形成5、6或7个取代或不取代的环;每个R5应从氢，取代或未取代的c1-8，取代或未取代的Alquenilo C2-8，取代或未取代的C2-8，取代或未取代的c2-8-沥青组成的一组混合物中分别选择。-C（O ）RC（O）NR RS（O）RS（O）2R-S（O）2NR R1。 Arilo C6-10取代或未取代的，5-10取代或未取代的，3-10取代或未取代的异构化;和R'，R y R子cada uno en forma独立性hidrogeno o alquilo C1-4否sustituido o R y R junto con los tomos que sustituyen forman un anillo de 5 6 o 7 miembros sustituido o no sustituido

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