A MALDI/LDI source includes an ion collection device, e.g., a skimmer, orifice, mass analyzer, ion transfer optics and/or ion guide, configured for use with a short focal length lens with a large aperture. In some embodiments, the ion collection device includes an outer edge that can be disposed approximately parallel to a beam envelope between a lens and a focal point positioned at a MALDI/LDI sample. This configuration of the outer edge allows the ion collection device to be placed in close proximity to the focal point. This placement results in favorable collection efficiencies of laser desorbed analyte from the MALDI/LDI sample.
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