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Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity

机译:缺乏端粒酶催化活性的人端粒酶逆转录酶突变蛋白

摘要

The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
机译:本发明提供了与人端粒酶逆转录酶(hTRT)有关的组合物和方法,hTRT是人端粒酶的催化蛋白亚基。本发明的多核苷酸和多肽可用于人类疾病的诊断,预后和治疗,改变细胞和生物体的增殖能力以及用于鉴定和筛选可用于治疗诸如癌症的疾病的化合物和治疗。

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